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KMID : 0370219860300040180
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Yakhak Hoeji
1986 Volume.30 No. 4 p.180 ~ p.184
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Determination of Carboxyl Drugs by Gas Chromatography
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Abstract
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Such carboxyl drugs as mefenamic acid, alclofenac, ketoprofen, cicloxilic acid and tolfenamic acid in rat plasma were determined by the gas chronatography flame photometric detector (GC-FPD). After methylthiomethyl (MTM) esterification with MTM-chloride in 1, 8-diazabicyclo C5. 4. 0) undec-7-ene (DBU) catalyst, determination of these drugs by this method was tried and compared with that by the GC-flame ionization detector (FID) method in respect to sensitivity and effect of inteferences.
The results showed it was possible to analyze with accuracy by this method because of specificity of the FPD, although these drugs were not separated from interferences in plasma on GC column. The GC-FPD method was more sensitive than GC-FID method and the minimum detectable amount of monocarboxylic drugs on 3% QF-1 column was about 15fmol/injection.
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KEYWORD
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